منابع مشابه
Networking metabolites and diseases.
B iological systems are increasingly viewed and analyzed as highly complex networks of interlinked macromolecules and metabolites. Network analysis has been applied to interactome maps of protein–protein, protein–DNA, and protein–RNA interactions as well as transcriptional, metabolic, and genetic data. Such network views of biological systems should facilitate the detection of nonlinear long-ra...
متن کاملMaterials and Metabolites of Kynureinine Pathway in Neurodegenerative Diseases and Multiple Sclerosis
Abstract Background & aim: Kynurenine pathway (KP) plays an important role in the pathogenesis of neuroinflammation and neurodegenerative disorders. In neurodegenerative diseases (NDD) such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD) and Multiple sclerosis (MS), brain neurons are initially involved and gradually disappear. In the present review article, the ...
متن کاملE-I Balance and Human Diseases – from Molecules to Networking
Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I) balance, and it reviews examples of deregu...
متن کاملFlavonoids and Their Metabolites: Prevention in Cardiovascular Diseases and Diabetes
The occurrence of atherosclerosis and diabetes is expanding rapidly worldwide. These two metabolic disorders often co-occur, and are part of what is often referred to as the metabolic syndrome. In order to determine future therapies, we propose that molecular mechanisms should be investigated. Once the aetiology of the metabolic syndrome is clear, a nutritional intervention should be assessed. ...
متن کاملUrinary tryptophan metabolites in rheumatoid arthritis and some other diseases.
Previous studies from this laboratory have shown that a majority of patients with rheumatoid arthritis excrete abnormally high amounts of 3-hydroxyanthranilic acid and kynurenine (Bett, 1962a, b). A more striking finding was the rise in kynurenine output after tryptophan loading in rheumatoid arthritis. Administration of large doses of pyridoxine over a short period caused a temporary fall in k...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0805644105