Networking erythropoiesis
نویسندگان
چکیده
منابع مشابه
Networking erythropoiesis
A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene expression profiling, and comprehensive bioinform...
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STRONG EVIDENCE has accumulated to indicate that erythropoiesis in mammals is under the control of a circulating principle, the erythropoiesisstimulating factor ( ESF ) or erythropoietin.1’2 A similar regulatory system may be operative in amphibians and birds.3’4 The ESF appears in large quantities in the plasma of animals subjected to bleeding or low oxygen pressures’ and its production is inh...
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A B S TR A C T A major factor in the anemia of infection, inflammation, and malignancy is a relative failure of the bone marrow to increase erythropoiesis in response to a shortened red cell survival. The possible causes for this diminished marrow response are: (a) a reduced production of erythropoietin, or, (b) impaired bone marrow response to erythropoietin. In this report studies were perfor...
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Through their oxygen delivery function, red blood cells are pivotal to the healthy existence of all vertebrate organisms. These cells are required during all stages of life--embryonic, fetal, neonatal, adolescent, and adult. In the adult, red blood cells are the terminally differentiated end-product cells of a complex hierarchy of hematopoietic progenitors that become progressively restricted t...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2010
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20102260