Network of co-expressed circadian genes, childhood maltreatment and sleep quality in bipolar disorders

Bipolar disorder (BD) is a chronic and burdensome psychiatric disease, characterized by variations in mood energy. The literature has consistently demonstrated an association between BD childhood maltreatment (CM), genetic variants of circadian genes have been associated with increased vulnerability to develop BD. In this context, environmental factors such as CM may also contribute the susceptibility through alterations functioning biological clock linked modifications expression genes. study, we explored associations maltreatment, sleep quality, level comprehensive set lymphoblastoid cell lines from patients sample consisted 52 Caucasian euthymic diagnosis type 1 or 2. exposure was assessed Childhood Trauma Questionnaire (CTQ), quality using Pittsburgh Sleep Quality Index. We measured 18 quantitative RT-PCR: ARNTL2, BHLHE40, BHLHE41, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, DBP, GSK3B, NPAS2, NR1D1, PER1, PER2, PER3, PPARGC1A, RORA, RORB. Gene networks were analyzed disjoint graphs method. Compared other investigated transcripts, PPARGC1A only one whose differentially affected who experienced and, more specifically, physical abuse. observed no significant effects CTQ subscores (emotional sexual abuses, emotional neglects), nor on network expression. Although requiring replication larger cohorts, result obtained here consistent hypothesis influence systems highlights importance these processes.