Network biology methods integrating biological data for translational science

Network biology methods integrating biological data for translational science

The explosion of biomedical data, both on the genomic and proteomic side as well as clinical data, will require complex integration and analysis to provide new molecular variables to better understand the molecular basis of phenotype. Currently, much data exist in silos and is not analyzed in frameworks where all data are brought to bear in the development of biomarkers and novel functional tar...

Technologies for Integrating Biological Data

The process of building a new database relevant to some field of study in biomedicine involves transforming, integrating and cleansing multiple data sources, as well as adding new material and annotations. This paper reviews some of the requirements of a general solution to this data integration problem. Several representative technologies and approaches to data integration in biomedicine are s...

Integrating Biology and Climate Through Systems Science

The genomic and postgenomic eras have provided unprecedented potential to understand plants’, microbes’, and even entire communities’ molecular and cellular responses to global change. Early efforts to apply genomic technologies and concepts to climate change research are already improving our capability to predict organism response to such change. For example, genome-wide analyses of soybean a...

Formal Methods of Computer Science for Biology

Integrating economic evaluation methods into clinical and translational science award consortium comparative effectiveness educational goals.

With the ongoing debate over health care reform in the United States, public health and policy makers have paid growing attention to the need for comparative effectiveness research (CER). Recent allocation of federal funds for CER represents a significant move toward increased evidence-based practice and better-informed allocation of constrained health care resources; however, there is also hea...