Netrin-1 interacts with amyloid precursor protein and regulates amyloid-β production
نویسندگان
چکیده
منابع مشابه
Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth.
The multifunctional protein netrin-1 was initially discovered as the main attractive cue for commissural axon guidance by acting through its receptor DCC. Recently, we have shown that netrin-1 also interacts with the orphan transmembrane receptor amyloid precursor protein (APP). APP is cleaved by proteases, generating amyloid-β peptide, the main component of the amyloid plaques that are associa...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2009
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2008.191