NET TREFFERS TEL

Tel-Aviv University

Hebrew) ................................................................................................................................. i Abstract ................................................................................................................................................ iii 1. Idioms: History, Theory and Research Questions ....................................................

Tel Aviv University

Tel Aviv University

We all have strong intuitions about a connection between Coordination and the notion of "equivalence" (Hebrew: , תוליקש). This is reflected by the fact that researchers often use terms like ‘parallelism’, ‘similarity’, or ‘symmetry’ when providing structural definitions of coordinated constructions (e.g., Azar 1977; Haspelmath, 2007; Van Valin 1990). Certain questions, such as the following, re...

TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell lines.

The t(12;21) (p 13; q22) results in the fusion of the TEL gene located on chromosome 12 with the AML1 gene located on the derivative chromosome 21. Because this translocation is difficult to detect using standard cytogenetic techniques, 27 previously karyotyped B-lineage acute lymphoblastic leukemia (ALL) cell lines were evaluated for the presence of the TEL-AML1 fusion using the reverse transc...

The Leukemia-Associated Fusion Protein MN1-TEL Blocks TEL-Specific Recognition Sequences

The leukemia-associated fusion protein MN1-TEL combines the transcription-activating domains of MN1 with the DNA-binding domain of the transcriptional repressor TEL. Quantitative photobleaching experiments revealed that ∼20% of GFP-tagged MN1 and TEL is transiently immobilised, likely due to indirect or direct DNA binding, since transcription inhibition abolished immobilisation. Interestingly, ...