Net closes in on genetics of liver fluke-associated cholangiocarcinoma
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چکیده
منابع مشابه
Cholangiocarcinoma Associated with Liver Fluke Infection in an Iranian Patient
Biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. Clonorchis sinensis and Opisthorchis species are the major biliary liver flukes associated with human disease. Some of these parasites are highly associated with cholan...
متن کاملcholangiocarcinoma associated with liver fluke infection in an iranian patient
biliary liver flukes are common parasites in some regions of the world where consumption of raw fresh-water fish is a cultural practice. clonorchis sinensis and opisthorchis species are the major biliary liver flukes associated with human disease. some of these parasites are highly associated with cholangiocarcinoma. this report describes a clinically and epidemiologically unsuspected liver flu...
متن کاملLiver Fluke Induces Cholangiocarcinoma
Liver fl uke infection caused by Opisthorchis viverrini, O. felineus, and Clonorchis sinensis is a major public health problem in East Asia and Eastern Europe. Currently, more than 600 million people are at risk of infection with these trematodes [1]. O. viverrini is endemic in Southeast Asian countries, including Thailand, Lao People’s Democratic Republic, Vietnam, and Cambodia [2], and C. sin...
متن کاملCD44 variant‐dependent redox status regulation in liver fluke‐associated cholangiocarcinoma: A target for cholangiocarcinoma treatment
Expression of CD44, especially the variant isoforms (CD44v) of this major cancer stem cell marker, contributes to reactive oxygen species (ROS) defense through stabilizing xCT (a cystine-glutamate transporter) and promoting glutathione synthesis. This enhances cancer development and increases chemotherapy resistance. We investigate the role of CD44v in the regulation of the ROS defense system i...
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At the turn of the last century, Africa faced an epidemic of sleeping sickness. For a while in the 70’s, with the advent and targeted use of insecticides like DDT, it seemed the disease would be eradicated. Today, Africa faces another sleeping sickness epidemic, which it seems little better equipped to respond to than it was a century ago and sleeping sickness looks to be a disease which may be...
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ژورنال
عنوان ژورنال: Nature Reviews Gastroenterology & Hepatology
سال: 2012
ISSN: 1759-5045,1759-5053
DOI: 10.1038/nrgastro.2012.99