Nervous chemokines

Nervous chemokines

Nervous chemokines uidance molecules from the immune and nervous systems are getting mixed up in each others business. have found that a leukocyte attractant called stromal-derived factor 1 (SDF-1) is the main factor that entices embryonic cerebellar neurons to their correct location. SDF-1 is a chemokine—a peptide that attracts leukocytes by activating a G protein signaling cascade. In contras...

Chemokines in systemic lupus erythematosus involving the central nervous system.

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multi-organ damage and neuropsychiatric complications (NPSLE) associated with increased morbidity and mortality. The pathogenesis of NPSLE is not yet fully understood, but focal symptoms are thought to most likely result from vascular lesions, whereas diffuse manifestations are more likely related to autoantibody- or c...

Chemokines.

Chemokines.

not been systematically examined. Similar clustering has C been observed among genes encoding chemokine receptors. HEMOKINES have recently become the focus of intense interest and discussion. This has occurred, in One exception to the CC/CXC rule is lymphotactin, a part, because of an enlarging view of what chemokines do. potent attractant for T lymphocytes, but not monocytes. As recently as 2 ...

Chemokines and Heart Disease: A Network Connecting Cardiovascular Biology to Immune and Autonomic Nervous Systems

Among the chemokines discovered to date, nineteen are presently considered to be relevant in heart disease and are involved in all stages of cardiovascular response to injury. Chemokines are interesting as biomarkers to predict risk of cardiovascular events in apparently healthy people and as possible therapeutic targets. Moreover, they could have a role as mediators of crosstalk between immune...