Nerve Degeneration

Optic Nerve Degeneration and Ageing

Major pathological hallmarks of Alzheimer Disease are insoluble deposits of the short amyloid β-peptide (β-amyloid, Aβ), which is derived by sequential proteolytic cleavage from a large type I trans-membrane protein, the β-amyloid precursor protein (APP). APP is anterogradely transported by fast axonal transport in a distinct transport vesicle, but both the biochemical composition of such a ves...

Temperature Coefficient of Nerve Degeneration.

P187: Dose-Dependent Delay of Wallerian Degeneration Induced by Dexamethasone after Sciatic Nerve Transection in Rat

Wallerian degeneration is an innate immune response which occurs after some kinds of nerve damages such as neurodegenerative disease and acute axonal injury. In clinic, dexamethasone as an anti-inflammatory drug has been used for many years to treat nerve injuries. In present study, we aimed to study the effects of various doses of dexamethasone on the Wallerian degeneration in rat. Twentyseven ...

Cutaneous nerve terminal degeneration in painful mononeuropathy.

Nociceptive nerves innervate the skin and play an important role in the generation of neuropathic pain. However, it remains elusive whether and how nociceptive nerve terminals degenerate in neuropathic pain conditions. To address this issue, we investigated cutaneous innervation in a model of painful mononeuropathy, the chronic constriction injury (CCI). The hind paws of rats were immunocytoche...

Descending optic nerve degeneration in primates.

We cut the optic nerve at the orbital apex in squirrel monkeys to study the descending degeneration of optic nerve axons and their ganglion cell bodies. We could not detect progressive disintegration of the axon from the site of injury back to the cell body. Instead, the entire length of individual axons seemed to degenerate simultaneously as early as 3 weeks and as late as 6 weeks after injury...