Nephrogenic systemic fibrosis (NSF): the role of tamoxifen
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منابع مشابه
Nephrogenic systemic fibrosis (NSF): the role of tamoxifen
Dear Sir, Nephrogenic systemic fibrosis (NSF) is exclusively found in patients with marked renal impairment who have been exposed to gadolinium (Gd) through its use as a contrast agent in magnetic resonance imaging (MRI) studies [1]. The main clinical feature of NSF is thickening and hardening of the skin, and joint contractures are common. There is no confirmed effective treatment for NSF and ...
متن کاملNephrogenic Systemic Fibrosis (NSF)
When first described in 2000, NSF was noted to occur predominantly in patients with end-stage chronic kidney disease (CKD), particularly in patients on dialysis. In 2006 several groups noted a strong association between gadolinium-based contrast agent (GBCA) administration in patients with advanced renal disease and the development of NSF [1,2], and it is now generally accepted that GBCA exposu...
متن کاملNephrogenic systemic fibrosis.
Nephrogenic systemic fibrosis is a recently diagnosed disease that occurs in patients with chronic kidney disease and acute renal failure. The patients develop skin thickening and fibrosis which is usually symmetrical, and typically of the upper and lower extremities. In some cases the progression is rapid leading to joint contractures confining the patient to a wheelchair. Systemic involvement...
متن کاملNephrogenic systemic fibrosis
Nephrogenic systemic fibrosis, initially called nephrogenic fibrosing dermopathy, has been strongly linked to exposure to gadolinium-based contrast media used in magnetic resonance imaging in patients with renal insufficiency. This review discusses recent advances in our understanding of the pathophysiology and clinical approach to patients with chronic kidney disease who require diagnostic ima...
متن کاملUnderstanding Nephrogenic Systemic Fibrosis
Nephrogenic systemic fibrosis (NSF) is a rare and a debilitating disease noted uncommonly in patients with impaired renal function when exposed to low-stability gadolinium-based contrast agents (Gd-CAs). According to experimental studies, cytokines released by the stimulation of effector cells such as skin macrophages and peripheral blood monocytes activate circulating fibroblasts which play a ...
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ژورنال
عنوان ژورنال: Clinical Kidney Journal
سال: 2010
ISSN: 2048-8505,2048-8513
DOI: 10.1093/ndtplus/sfq111