Neoplastic Paneth cells

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Neoplastic Paneth cells1

Paneth cells were discovered by Schwalbe in 1872 and described more fully by Paneth in 1888. They have been found since in the intestinal mucosa of a wide variety of animals. They are found in the fundus of the crypts of Lieberkuhn and their characteristic feature is the large granules visible in both the fresh and fixed state in the apical or upper part of the cell (Fig. 1). In man they occur ...

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Paneth cells

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Neoplastic Paneth cells in the experimental murine carcinoma of the small intestine.

The purpose of this study is to elucidate the participation of Paneth cells in experimentally induced adenocarcinoma of the intestine. The rats were fed with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) dissolved in drinking water ad libitum at a concentration of 100 micrograms/ml for 28 weeks. They were sacrificed 12 weeks after the last MNNG administration. A number of tumor cells containing l...

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Paneth cells and necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Immaturity of the innate immune system of the gut is central to the pathogenesis of NEC. Recent studies suggest a key role for Paneth cells in this disease. Addressing basic questions on the development and function of immature Paneth cells may shed light on the puzzling pathophysiology of NEC. Current ani...

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Effect of photo–electron therapy on human neoplastic cells

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1968

ISSN: 0021-9746

DOI: 10.1136/jcp.21.4.476