Neonatal lupus syndrome
نویسندگان
چکیده
منابع مشابه
[Neonatal lupus syndrome].
Neonatal lupus syndrome is a passively acquired autoimmune syndrome in which pathogenic autoantibodies (anti-SSA/Ro, anti-SSB/La, and both, or rarely anti-U(1)RNP antibodies) are transmitted from a mother to her fetus through the placenta. The major clinical manifestations in the infants are cardiac (congenital heart block), dermatologic (skin lesion), hepatic (elevated hepatic enzymes), and he...
متن کاملCutaneous Lupus Erythematosus in Neonates and Infants: Maternally Derived Autoimmunity and the Neonatal Lupus Syndrome
Neonates are not sufficiently immunologically competent to develop IgG autoantibody–mediated disease independently. However, IgG autoantibodies from the mother transmitted in utero can initiate disease in susceptible individuals. In a small percentage of fetuses and neonates exposed to maternal autoantibodies of the Ro/SSA family, an autoimmune disease called “neonatal lupus erythematosus (NLE)...
متن کاملHeart involvement in systemic lupus erythematosus, anti-phospholipid syndrome and neonatal lupus.
Cardiac involvement is one of the main complications substantially contributing to the morbidity and mortality of patients suffering from systemic autoimmune diseases. All the anatomical heart structures can be affected, and multiple pathogenic mechanisms have been reported. Non-organ-specific autoantibodies have been implicated in immune complex formation and deposition as the initial triggers...
متن کاملNeonatal Lupus Erythematosus
Neonatal lupus erythematosus (NLE) refers to a clinical spectrum of cutaneous, cardiac, and systemic abnormalities observed in newborn infants whose mothers have autoantibodies against Ro/SSA and La/SSB. The condition is rare and usually benign and self-limited but sometimes may be associated with serious sequelae. We review the pathophysiology, clinical features, and management of infants with...
متن کاملNeonatal Lupus Erythematosus (NLE)
Neonatal lupus erythematosus (NLE) or neonatal lupus syndrome (NLS) is a rare syndrome seen in 1-2% of neonates with auto-antibodies to SSA/Ro, SSB/La and or U1 RNP, passively transferred transplacentally from the mother who is either asymptomatic or having manifestations of Sjogren’s syndrome, SLE or other systemic rheumatic disease, characterized by cutaneous, cardiac or rarely both clinical ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 2005
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.28.4