Nematospiroides dubius: factors affecting the primary response to SRBC in infected mice
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منابع مشابه
The effect of gamma irradiation on Nematospiroides dubius. Factors affecting the survival of worms in a primary infection in mice.
The infective larvae of Nematospiroides dubius were exposed to various levels (0-30 krad) of gamma irradiation by means of a Cobalt 60 source. Groups of mice were infected with these larvae and autopsied 5 weeks later for worm counts. It was found that male worms were more susceptible to irradiation than female worms. In both instances, however, the survival curve on a semi logarithmic plot was...
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The efficacy of ivermectin against Heligmosomoides polygyrus was investigated in 5 mouse strains (CFLP, NIH, C57Bl10, BALB/c and CBA) using a variety of dose levels, and subcutaneous and oral administration. Heligmosomoides polygyrus were not completely eliminated when 5 mg kg-1 of ivermectin was given 6 days after infection, but 10 mg kg-1 was totally effective. Significant mouse-strain variat...
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Primary immune expulsion of Trichuris muris was markedly delayed by concurrent infection with Nematospiroides dubius. Maximum delay of expulsion was dependent on size and timing of N. dubius infection relative to T. muris infection. In NIH mice infection with 400 N. dubius larvae immediately before or after T. muris infection was found to be most effective in suppressing expulsion. Infection on...
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Infective larvae of Nematospiroides dubius attenuated by cobalt 60 irradiation are extremely effective at stimulating immunity. Previously, such levels of protection could only be obtained with multiple immunizations of normal larvae. The critical factor underlying this protective response appears to be the dose of irradiation given to the immunizing infection. Various doses of irradiation have...
متن کاملImmunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): parasite specific IgG1 antibody responses and primary response phenotype.
IgG1 antibody responses to Heligmosomoides polygyrus were measured in eight mouse strains supporting acute (< 8 weeks, SJL, SWR), intermediate (10-20 weeks, NIH, BALB/c) or chronic (> 25 weeks, C57BL/0, CBA, C3H, AKR) primary infections. Mice supporting acute or intermediate infections produced more intense antibody responses and total serum IgG1 concentrations were higher than in mice tolerati...
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ژورنال
عنوان ژورنال: Journal of Helminthology
سال: 1983
ISSN: 0022-149X,1475-2697
DOI: 10.1017/s0022149x00011068