Neisseria meningitidis: pathogenesis and immunity
نویسندگان
چکیده
منابع مشابه
Neisseria meningitidis: pathogenesis and immunity.
The recent advances in cellular microbiology, genomics, and immunology has opened new horizons in the understanding of meningococcal pathogenesis and in the definition of new prophylactic intervention. It is now clear that Neissera meningitidis has evolved a number of surface structures to mediate interaction with host cells and a number of mechanisms to subvert the immune system and escape com...
متن کاملUnraveling Neisseria meningitidis pathogenesis: from functional genomics to experimental models
Neisseria meningitidis is a harmless commensal bacterium finely adapted to humans. Unfortunately, under "privileged" conditions, it adopts a "devious" lifestyle leading to uncontrolled behavior characterized by the unleashing of molecular weapons causing potentially lethal disease such as sepsis and acute meningitis. Indeed, despite the lack of a classic repertoire of virulence genes in N. meni...
متن کاملVaccine-induced opsonophagocytic immunity to Neisseria meningitidis group B.
The role of opsonophagocytosis (OP) in protection against meningococcal disease is controversial because patients with deficiencies in terminal complement proteins whose sera support OP but not bactericidal activity (BA) are at greatly increased risk of disease. We assayed complement-mediated BA and OP bactericidal activity in sera from 32 adults immunized with an outer membrane vesicle vaccine...
متن کاملNasopharyngeal colonization by Neisseria lactamica and induction of protective immunity against Neisseria meningitidis.
BACKGROUND Natural immunity to Neisseria meningitidis may result from nasopharyngeal carriage of closely related commensals, such as Neisseria lactamica. METHODS We enrolled 61 students with no current carriage of Neisseria species and inoculated them intranasally with 10,000 colony-forming units of Neisseria lactamica or sham control. Colonization was monitored in oropharyngeal samples over ...
متن کاملNeisseria meningitidis W135, Turkey
We describe the first case of Neisseria meningitidis W135 meningitis in Turkey. The strain was genotypically unrelated to the clone (W)ET-37, isolated from Hajj pilgrims in 2000.
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ژورنال
عنوان ژورنال: Current Opinion in Microbiology
سال: 2015
ISSN: 1369-5274
DOI: 10.1016/j.mib.2014.11.006