Negative Symptoms and Cognitive Impairments in Schizophrenia: Two Key Symptoms Negatively Influencing Social Functioning

The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments.

OBJECTIVE Patients with schizophrenia frequently present with negative symptoms and cognitive impairments for which no effective treatments are known. Agents that act at the glycine site of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising treatments for moderate to severe negative symptoms and cognitive impairments. METHOD The Cognitive and Negative ...

Social Cognition in Schizophrenia: Relations between ToM Impairments and Symptoms

Social competence versus negative symptoms as predictors of real world social functioning in schizophrenia.

Deficits in real world social functioning are common in people with schizophrenia and the treatment of social skills deficits has been a long-time treatment strategy. However, negative (i.e., deficit) symptoms also appear to contribute to real-world social dysfunction. In this study, we combined data from three separate studies of people with schizophrenia (total n=561) who were assessed with i...

The Effects of Bupropion on Negative Symptoms in Schizophrenia

Abstract:Purpose:This study was designed determine the efficacy of bupropion versus placebo in subjects with negative symptoms of schizophrenia.Methods:A convenience sample of 40 patients of both genders aged 18-60 years who were living in psychiatric care centers were randomly treated with bupropion (started with 75 mg twice a day; increased to 100 mg thrice daily) or placebo. The diagnosis of...

Negative Symptoms and Negative Schizophrenia

This study determines the frequency distribution of prominent negative symptoms in a group of chronic, hospitalised schizophrenics. Thirty chronic Schizophrenic (D.S.M. III) patients were rated on the scale for Assessment of Negative Symptoms (SANS) and the prominent negative symptoms were correlated with age, sex and certain illness variables. Majority (80%) of patients had some or the other n...