Negative regulation of B cell responses and self-tolerance to RNA-related lupus self-antigen
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چکیده
منابع مشابه
Negative regulation of B cell responses and self-tolerance to RNA-related lupus self-antigen
The antibody response to RNA-related antigens such as Sm/RNP requires the endosomal RNA sensor TLR7, and this process is crucial in the development of systemic lupus erythematosus at least in animal models. The inhibitory B cell receptor CD72 is unique because it recognizes Sm/RNP and specifically inhibits the activation of Sm/RNP-reactive B cells by activating SH2-containing protein tyrosine p...
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ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 2018
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.94.003