Negative Correlation between Serum Brain-derived Neurotrophic Factor Levels and Obesity Predictor Markers and Inflammation Levels in Females with Obesity
نویسندگان
چکیده
BACKGROUND: Obesity has been widely associated with structural and functional changes in the brain, whereas inflammation is one of potential mechanisms involved these changes.
 OBJECTIVE: This study aims to prove relationship between serum brain-derived neurotrophic factor (BDNF) levels obesity predictor markers (body mass index waist hip ratio) (interleukin-6 Tumor Necrosis Factor-alpha) females obesity.
 METHODS: used a cross-sectional method using 33 aged 19-23 years, body (BMI) > 27.5 kg/m2, normal blood pressure, resting heart rate (RHR), hemoglobin (Hb), fasting glucose (FBG) ? 100 mg/dL. The examination BDNF, IL-6, TNF-? Enzyme-Linked Immunosorbent Assay (ELISA) method. data were analyzed Pearson product-moment test significant p<0.05.
 RESULTS: results indicated that there negative correlation BDNF BMI (r = –0.759; p<0.001), WHR –0.675; IL-6 –0.530; p<0.001) –0.561; p<0.001).
 CONCLUSION: Based on study, BMI, ratio, obesity. Further studies are needed confirm present findings.
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ژورنال
عنوان ژورنال: Open Access Macedonian Journal of Medical Sciences
سال: 2021
ISSN: ['1857-9655']
DOI: https://doi.org/10.3889/oamjms.2021.6840