Negative Chronotropic Response to Norepinephrine
نویسندگان
چکیده
منابع مشابه
Chronotropic Effects of Norepinephrine and Tyramine: a System Response Analysis.
• In 1958, Burn and Rand 1 proposed that the drug, tyramine, had no direct sympathomimetic effects and that its pharmacologic action was wholly mediated by the liberation of norepinephrine from endogenous stores. This was based upon the observation that preparations severely depleted of stored norepinephrine by pretreatment with reserpine responded poorly, if at all, to tyramine. Large amounts ...
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Twelve healthy volunteers were given one week's oral treatment with each of 300 mg nizatidine, 40 mg famotidine, and placebo once daily in a randomised, placebo controlled, double blind study. Three hours after administration, nizatidine led to a significant reduction in the mean (SD) resting heart rate compared with placebo (63.6 (6.4) beats/minute on placebo to 55.9 (7.2) beats/minute on niza...
متن کاملNegative inotropic and chronotropic effects of oxytocin.
We have previously shown that oxytocin receptors are present in the heart and that perfusion of isolated rat hearts with oxytocin results in decreased cardiac flow rate and bradycardia. The mechanisms involved in the negative inotropic and chronotropic effects of oxytocin were investigated in isolated dog right atria in the absence of central mechanisms. Perfusion of atria through the sinus nod...
متن کامل[Effects of cimetidine on chronotropic response to cardiopulmonary exercise testing].
OBJECTIVE To test the hypothesis that the administration of cimetidine will modify the chronotropic response to exercise testing through a random clinical trial. METHODS The study selected 24 eligible healthy subjects, ages between 20 and 68 years, not athletes, who agreed to undergo cardiopulmonary exercise testing after the administration of placebo and 400 mg of cimetidine twice a day for ...
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BACKGROUND While exercise-based cardiac rehabilitation has a beneficial effect on heart failure hospitalization and mortality, it is limited by the presence of chronotropic incompetence (CI) in some patients. This study explored the feasibility of using wearable devices to assess impaired chronotropic response in heart failure patients. METHODS Forty patients with heart failure (left ventricu...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 1974
ISSN: 0021-4868,1348-673X
DOI: 10.1536/ihj.15.308