Negative autoregulation of Oct3/4 through Cdx1 promotes the onset of gastrulation
نویسندگان
چکیده
منابع مشابه
17-P011 Oct3/4 activates Cdx1 to terminate pluripotency at the onset of gastrulation
Gastrulation is characterized by the differentiation of pluripotent cells to generate the germ layers, morphogenetic movements, a decrease in cell proliferation and establishment of the embryonic axes. We show by Cdx1 knock-down that it functions as a regulator of the onset of gastrulation in agreement with its early expression. In a microarray-based approach to search for Cdx1 targets, we iden...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2011
ISSN: 1058-8388
DOI: 10.1002/dvdy.22588