Near-infrared emitting fluorescent homobimetallic gold(I) complexes displaying promising in vitro and in vivo therapeutic properties
نویسندگان
چکیده
Three near-infrared (NIR-I) optical theranostic systems were synthesized, characterized and studied in vitro vivo. These original homo-bimetallic gold(I)-based aza-BODIPY complexes proved to be trackable through imaging cells mice. They display anti-proliferative properties micromolar range against human murine cancer cell lines (4T1, MDA-MB-231, CT26, SW480). Moreover, the injection of most promising agent CT26 tumor-bearing BALB/c mice induced a significant anti-cancer activity.
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2021
ISSN: ['0009-4374']
DOI: https://doi.org/10.1016/j.ejmech.2021.113483