Near-infrared carbon nanodots for effective identification and inactivation of Gram-positive bacteria

An unacceptable increase in antibacterial resistance has arisen due to the abuse of multiple classes broad-spectrum antibiotics. Therefore, it is significant develop new agents, especially those that can accurately identify and kill specific bacteria. Herein, we demonstrate a kind perilla-derived carbon nanodots (CNDs), integrating intrinsic advantages luminescence photodynamic, providing opportunity The CNDs have an exotic-doped π-conjugated core, vitalizing them near-infrared (NIR) absorption emission properties with photoluminescence quantum yield 21.1%; hydrophobic chains onto surface make selectively stain Gram-positive bacteria by insertion into their membranes. Due strong NIR region, reactive oxygen species are situ generated bacterial membranes under 660 nm irradiation, 99.99% inactivation efficiency against within 5 min be achieved. In vivo results photodynamic property eliminate inflammation area affected methicillin-resistant Staphylococcus aureus (MRSA), enabling wound cured quickly.