منابع مشابه
Essential roles for the nuclear receptor coactivator Ncoa3 in pluripotency
Embryonic stem cells (ESCs) are valuable tools for regenerative medicine, being capable of self-renewing in culture indefinitely while retaining their pluripotency, i.e., the ability to generate any cell of the adult organism. At the heart of these capabilities is a complex transcriptional network, which carefully guards an uncommitted state, yet permits ESCs to remain poised for differentiatio...
متن کاملNCOA 4 ( Nuclear Receptor Coactivator 4 )
NCOA4 is involved in the androgen receptor signaling pathway and in the development of the male gonade. It is a ligand-dependent associated protein for the androgen receptor (AR), that functions as coactivator to enhance AR transcriptional activity (7-10 fold in human prostate cancer cells) and protein stability. NCOA4 also enhances the agonist activity of anti-androgens in human prostate cance...
متن کاملGAC63, a GRIP1-dependent nuclear receptor coactivator.
Nuclear receptors (NRs) regulate target gene transcription through the recruitment of multiple coactivator complexes to the promoter regions of target genes. One important coactivator complex includes a p160 coactivator (GRIP1, SRC-1, or ACTR) and its downstream coactivators (e.g., p300, CARM1, CoCoA, and Fli-I), which contribute to transcriptional activation by protein acetylation, protein met...
متن کاملThe Nuclear Receptor Coactivator Amplified in Breast
Overexpression of the oncogene amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) induces mammary tumorigenesis in mice. In breast cancer, high levels of AIB1/SRC-3 and the growth factor receptor HER2/neu predict resistance to endocrine therapy and poor outcome. However, a mechanistic relationship between AIB1/SRC-3 and HER2/neu in the development of breast cancer has no...
متن کاملSRC-3 Has a Role in Cancer Other Than as a Nuclear Receptor Coactivator
Steroid receptor coactivator-3 (SRC-3), also known as AIB1, is a member of the p160 steroid receptor coactivator family. Since SRC-3 was found to be amplified in breast cancer in 1997, the role of SRC-3 in cancer has been broadly investigated. SRC-3 initially was identified as a transcriptional coactivator for nuclear receptors such as the estrogen receptor (ER), involved in the proliferation o...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/38207