Natural Selection Molds Genomic Insulator Elements
نویسندگان
چکیده
منابع مشابه
Natural Selection Molds Genomic Insulator Elements
The ‘‘modern synthesis’’ of evolutionary biology, first formulated in the early 20th century, combined the ideas of Mendelian genetics and Darwinian evolution to create an outline for evolutionary theory that stressed the central role of genes in evolutionary processes. Of the genetic changes that drive evolution, the earliest to be studied were in proteins with familiar and prominent roles in ...
متن کاملInference of natural selection from interspersed genomic elements based on polymorphism and divergence.
Complete genome sequences contain valuable information about natural selection, but this information is difficult to access for short, widely scattered noncoding elements such as transcription factor binding sites or small noncoding RNAs. Here, we introduce a new computational method, called Inference of Natural Selection from Interspersed Genomically coHerent elemenTs (INSIGHT), for measuring ...
متن کاملThe Genomic Distribution of L1 Elements: The Role of Insertion Bias and Natural Selection
LINE-1 (L1) retrotransposons constitute the most successful family of retroelements in mammals and account for as much as 20% of mammalian DNA. L1 elements can be found in all genomic regions but they are far more abundant in AT-rich, gene-poor, and low-recombining regions of the genome. In addition, the sex chromosomes and some genes seem disproportionately enriched in L1 elements. Insertion b...
متن کاملDetecting natural selection in genomic data.
The past fifty years have seen the development and application of numerous statistical methods to identify genomic regions that appear to be shaped by natural selection. These methods have been used to investigate the macro- and microevolution of a broad range of organisms, including humans. Here, we provide a comprehensive outline of these methods, explaining their conceptual motivations and s...
متن کاملA natural topological insulator.
The earth's crust and outer space are rich sources of technologically relevant materials which have found application in a wide range of fields. Well-established examples are diamond, one of the hardest known materials, or graphite as a suitable precursor of graphene. The ongoing drive to discover novel materials useful for (opto)electronic applications has recently drawn strong attention to to...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Biology
سال: 2012
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1001421