Natural Product Drug Discovery in the Next Millennium
نویسندگان
چکیده
منابع مشابه
Drug discovery in the next millennium.
Selection and validation of novel molecular targets have become of paramount importance in light of the plethora of new potential therapeutic drug targets that have emerged from human gene sequencing. In response to this revolution within the pharmaceutical industry, the development of high-throughput methods in both biology and chemistry has been necessitated. This review addresses these techn...
متن کاملGuiding principles for natural product drug discovery.
Natural products (NPs) have historically been a fertile source of new drugs for the pharmaceutical industry. However, this once-popular approach has waned considerably over the past two decades as the high-throughput screening of megalibraries comprised mainly of molecules with non-natural (synthetic) motifs has unfolded. Contemporary high-throughput screening libraries contain molecules compli...
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Although traditionally natural products have played an important role in drug discovery, in the past few years most Big Pharma companies have either terminated or considerably scaled down their natural product operations. This is despite a significant number of natural product-derived drugs being ranked in the top 35 worldwide selling ethical drugs in 2000, 2001, and 2002. There were 15 new nat...
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High-throughput biology has contributed a wealth of data on chemicals, including natural products (NPs). Recently, attention was drawn to certain, predominantly synthetic, compounds that are responsible for disproportionate percentages of hits but are false actives. Spurious bioassay interference led to their designation as pan-assay interference compounds (PAINS). NPs lack comparable scrutiny,...
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1 Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, 1113 Buenos Aires, Argentina 2Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain 3 Universidade do Vale do Itajaı́, Núcleo De Investigações Quı́mico-Farmacêuticas (NIQFAR), CCS, Brazil 4Department of Chemistry, University of Alabama in Huntsv...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 2001
ISSN: 1388-0209,1744-5116
DOI: 10.1076/phbi.39.s1.8.0009