Natural Product-Derived Drugs Based on β-Adrenergic Agents and Nucleosides

Natural product and natural product derived drugs in clinical trials.

There are a significant number of natural product (NP) drugs in development. We review the 100 NP and NP-derived compounds and 33 Antibody Drug Conjugates (ADCs) with a NP-derived cytotoxic component being evaluated in clinical trials or in registration at the end of 2013. 38 of these compounds and 33 ADCs are being investigated as potential oncology treatments, 26 as anti-infectives, 19 for th...

Natural Based Anticancer Drugs and Their Worthiness

Review of Natural Product-Derived Compounds as Potent Antiglioblastoma Drugs

Common care for glioblastoma multiforme (GBM) is a surgical resection followed by radiotherapy and temozolomide- (TMZ-) based chemotherapy. Unfortunately, these therapies remain inadequate involving severe mortality and recurrence. Recently, new approaches discovering combinations of multiple inhibitors have been proposed along with the identification of key driver mutations that are specific t...

Nucleosides: Metabolites and Drugs

movement of numerous nonlipophilic compounds across cell membranes and are likely to have evolved soon after the appearance of the lipid-based biological membrane. Any substance that must enter or leave a eukaryotic or prokaryotic cell and that is not soluble in lipid or small enough to diffuse between the constituent molecules that make up a membrane requires a specialized transport mechanism ...

Synthesis of spiroacetal-nucleosides as privileged natural product-like scaffolds.

The elaboration of a 6,6-spiroacetal scaffold to incorporate a nucleoside unit at the anomeric position is described. The novel spiroacetal-nucleoside hybrids were generated via nucleosidation of acetoxy-spiroacetal with a series of silylated nucleobases under Vorbrüggen conditions.