Natural Killer T cell obsession with self-antigens
نویسندگان
چکیده
منابع مشابه
Natural killer T cell recognition of lipid antigens
Natural killer T cells recognize lipid antigens in the context of CD1 molecules. Recent publications show that this mode of recognition differs substantially from that of classic T-cell receptor peptide-major histocompatibility complex interaction.
متن کاملPsychosine variants as antigens for natural killer T cells.
Natural killer T (NKT) cells play a central role in the interface between innate and adaptive immunity, and alpha-galactosylceramide was recently shown to be an endogenous antigen for these cells. The source of alpha-galactosylceramide has not yet been determined; however, in vivo degradation of alpha-galactosylceramide involves generation of alpha-psychosine (alpha-galactosylsphingosine). Alph...
متن کاملT cell regulation of natural killer cells
In light of their role in the immune response against tumors and viruses, natural killer (NK) cells represent a promising target for immunotherapy. Before this target is reached, the various mechanisms that control NK cell activity must first be identified and understood. In the past decades, studies have identified two critical processes that prevent spontaneous NK cell-mediated autoimmune act...
متن کاملAtypical natural killer T-cell receptor recognition of CD1d-lipid antigens.
Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex. However, the diversity of the NKT cell repertoire and the ensuing interactions with CD1d-antigen remain unclear. We describe an atypical population of CD1d-α-galactosylceramide (α-GalCer)-reactive human NKT cells that differ markedly from the prototypical TRAV10-TRAJ1...
متن کاملEsophageal natural killer (NK)/T cell lymphoma of true natural killer cell origin.
A 53-year-old man with no prior medical history was transferred to our hospital because of a 2-month history of dysphagia with throat pain. A complete blood count showed hemoglobin 14.2g/dL, and white blood cell count 11890/mL, and other laboratory findings were within normal limits. An enhanced computed tomography (CT) scan showed diffuse thickening of the esophageal wall without regional lymp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2013
ISSN: 0952-7915
DOI: 10.1016/j.coi.2013.01.002