Nasal Route: A Breakthrough for Drug Delivery

Development and discovery are the two important parameters of evolution. With progress pharmaceutical science technology, empirical route nose still remains one main attraction for formulation scientists. The nasal has capability to cover both topical systematic delivery. most part this is that we can target brain also. extent which a medicine may penetrate Blood Brain Barrier factors restricts capacity treatments treat illnesses Central Nervous System (CNS) (BBB). Tight junctions found in endothelial cells blood capillaries serve as barrier medications prevent them from passing through. BBB successfully prevents hydrophilic substances moving circulatory compartment tissue. between bulk passage across capillary walls, unlike other tissues. Nasal drug delivery strategies have emerged during last few decades, some be able circumvent difficulties getting cross BBB. Various neuro-degenerative disorders like migraine, Parkinson’s disease, Alzheimer's etc. targeted with particular path. This article will bring light on several features, strategies, obstacles pathway. Also, there dosage forms their evaluation provided. During preclinical studies, models designed in-vivo form. Among all others models, dog model so many advantages well suited performing any trial related intranasal