Nasal immunization with attenuated Salmonella Typhimurium expressing an MrpA–TetC fusion protein significantly reduces Proteus mirabilis colonization in the mouse urinary tract
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چکیده
منابع مشابه
Oral immunization of mice with attenuated Salmonella typhimurium aroA expressing a recombinant Mycoplasma hyopneumoniae antigen (NrdF).
Mycoplasma hyopneumoniae is the etiological agent of porcine enzootic pneumonia, a commercially expensive respiratory disease of swine. Salmonella typhimurium SL3261 was used as a live carrier of plasmid pKF1, which encodes a 15-kDa recombinant M. hyopneumoniae protein. This expressed recombinant protein consists of the carboxy-terminal 11 kDa of a 42-kDa M. hyopneumoniae NrdF ribonucleotide re...
متن کاملOral immunization of mice with vaccine of attenuated Salmonella typhimurium expressing Helicobacter pylori urease B subunit.
OBJECTIVE To prepare the live recombinant vaccine of attenuated Salmonella typhimurium SL3261 expressing Helicobacter pylori (H. pylori) B subunit (UreB) and to determine whether it could be used as an oral vaccine against H. pylori infection. METHODS Using genomic DNA of H. pylori Sydney strain (SSI) as template, the H. pylori UreB gene fragment was amplified by PCR and subcloned into the ex...
متن کاملUrinary Tract Infection Caused by a Capnophilic Proteus mirabilis Strain.
From a urine sample from a patient with a urinary tract infection, a carbon dioxide-dependent Proteus mirabilis strain was isolated. It is important to perform urine cultures in 5% carbon dioxide and an anaerobic atmosphere if bacteria prominent in Gram stains do not grow on routine media in ambient air.
متن کاملOral Immunization of Mice with Attenuated Salmonella Typhimurium Vaccine Expressing Transferrin-Binding Protein A (TbpA) of Haemophilus Parasuis
Background: Haemophilus parasuis is the etiological agent responsible for causing Glässer’s disease in pigs, which are major respiratory pathogens that cause large economic losses in the pig industry worldwide. H. parasuis obtains transferrinbound iron by expressing two surface receptors, transferrin-binding protein A and B (TbpA and B). The TbpA and B are capable of binding to transferrin, and...
متن کاملAn rfaH Mutant of Salmonella enterica Serovar Typhimurium is Attenuated in Swine and Reduces Intestinal Colonization, Fecal Shedding, and Disease Severity Due to Virulent Salmonella Typhimurium
Swine are often asymptomatic carriers of Salmonella spp., and interventions are needed to limit colonization of swine to enhance food safety and reduce environmental contamination. We evaluated the attenuation and potential vaccine use in pigs of a Salmonella enterica serovar Typhimurium mutant of rfaH, the gene encoding the RfaH antiterminator that prevents premature termination of long mRNA t...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 2011
ISSN: 0022-2615,1473-5644
DOI: 10.1099/jmm.0.030460-0