Narrative review of neurocognitive and quality of life tools used in brain metastases trials

: Development of brain metastases are common in patients with advanced malignancies leading to significant morbidity and mortality. Although overall survival is an important endpoint these patients, neurocognition health related quality life (HRQoL) more accurately highlights the impact disease its treatment on patients. Whole radiotherapy (WBRT) has historically played a key role management especially those multiple metastases. Clinical trials have supported use stereotactic radiosurgery (SRS) alone limited sparing neurocognitive function HRQoL as compared combination SRS plus WBRT. Furthermore, new systemic agents increasingly being used clinical practice shown promise The upcoming tasked defining guidelines that specific patient tumour factors incorporating radiation, surgery, therapy. validity findings rest rigor study methodology utilisation validated assessment tools for HRQoL. This review aims appraise summarise modern trials.