Naproxen inhibits spontaneous lung adenocarcinoma formation in KrasG12V mice
نویسندگان
چکیده
منابع مشابه
DOK2 Inhibits EGFR-Mutated Lung Adenocarcinoma
Somatic mutations in the EGFR proto-oncogene occur in ~15% of human lung adenocarcinomas and the importance of EGFR mutations for the initiation and maintenance of lung cancer is well established from mouse models and cancer therapy trials in human lung cancer patients. Recently, we identified DOK2 as a lung adenocarcinoma tumor suppressor gene. Here we show that genomic loss of DOK2 is associa...
متن کاملSpontaneous development of lung adenocarcinoma in the CADM1 gene-deficient mice
Aberration of cell adhesion is a critical step in the development and progression of human tumors. A tumor suppressor gene, CADM1(Cell adhesion molecule 1)/TSLC1(Tumor suppressor in lung cancer 1), was originally identified in non-small cell lung cancer (NSCLC) by its tumor suppressor activity in nude mice. CADM1 encodes an immunoglobulin superfamily cell adhesion molecule which is expressed in...
متن کاملHuman alpha-defensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude mice.
Human alpha-defensin-1 (HNP1), a small antimicrobial peptide, shows cytotoxicity to tumor cells in vitro and inhibitory activity for pathologic neovascularization in vivo. Here, we did a gene therapy with a plasmid that expresses a secretable form of HNP1 for assaying its antitumor activity. The expression and secretion of HNP1 were determined by reverse transcription-PCR and ELISA in vitro. We...
متن کاملCandida albicans Structural and Secreted Proteins Modulate CD4/CD8 Ratio in Tumor Infiltrating Lymphocytes of Spontaneous Adenocarcinoma Bearing Mice
Background: Candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. It is speculated that structural and secretory proteins of C. albicans have immunomodulatory effects in cancer. Objective: To evaluate the effects of C. albicans structural and secreted proteins on intratumoral CD4/CD8 ratio as well as the survival rate in BALB/c t...
متن کاملFlax seed oil inhibits metastatic melanoma and reduces lung tumor formation in mice.
PURPOSE Cancer is one of the leading causes of mortality worldwide. Tumor cells circulating in the blood evidence the migration of tumor from the site of origin to another site leading to the formation of new metastatic lesion and establishment of metastatic tumors. In the present study, cultured metastatic tumor cells were injected into the C57BL/6 mice through tail-vein injection (TVI) and th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neoplasia
سال: 2021
ISSN: 1476-5586
DOI: 10.1016/j.neo.2021.05.010