Nanotoxicity in endodontics - the lurking hazards of nanomedicine

Molecular engineering has bought revolution into endodontics. Nanoparticles are particles of 1-100nm in dimension. Their small size, increased surface to volume ratio, specific properties and charge produces desirable for endodontic usage. It been incorporated sealers, obturating materials, restorative disinfectants etc name a few. However, there is other side it. These micrometre-sized can easily cross biological barriers, enter various organ systems the body causing damage at cellular level. ultrafine be “Nanotoxic”. Nanotoxicology study nature mechanism toxic effects nanoscale materials/particles on living organisms systems. deals with quantitative assessment severity frequency Nanotoxic relation exposure organisms. As next generation endodontics moves towards nanotechnology, it crucial develop proper understanding processes happening when nanoparticle comes contact system. Biocompatibility achieved material interacts without inducing any toxic, immunogenic, thrombogenic or carcinogenic response. Little known about toxicological impact these nanoparticles. This paper discusses nanotoxicity, factors affecting it, possible routes nanotoxicity endodontics, its methods assessment.