Nanostructured Insecticide Composition through the Incorporation of Natural Abamectin in ?-Cyclodextrin: Activity against Aedes aegypti Larvae

This study searched for a new pre-formulation based on the natural compound from class of avermectins, named abamectin (ABA), in order to improve its action against Aedes aegypti larvae by complexation with ?-cyclodextrin (?CD). Concerning low aqueous solubility ABA, even presence ?CD, it was also invoked strategy working hydrophobic nanoprecipitates (HNPs). For these purposes, molecular and supramolecular characterizations 1:1 ABA/?CD complex evaluation toxicity A. were performed. In physical-chemistry characterizations, changes infrared spectra thermal profiles relation precursors confirmed occurrence interactions between ABA ?CD solid state. Nuclear magnetic resonance (NMR) data suggest inclusion via benzofuran ring. Isothermal titration calorimetry (ITC) experiments allowed verify formation stoichiometry, which entropy driven. The dynamic light scattering zeta potential compounds demonstrated size HNP if compared HNP. Finally, results biological assays demonstrate that prepare led an increase larvicidal activity free ABA.