Nanoscale Strategies: Treatment for Peripheral Vascular Disease and Critical Limb Ischemia

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Nanoscale strategies: treatment for peripheral vascular disease and critical limb ischemia.

Peripheral vascular disease (PVD) is one of the most prevalent vascular diseases in the U.S. afflicting an estimated 8 million people. Obstruction of peripheral arteries leads to insufficient nutrients and oxygen supply to extremities, which, if not treated properly, can potentially give rise to a severe condition called critical limb ischemia (CLI). CLI is associated with extremely high morbid...

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Revascularization for critical limb ischemia (CLI), the most advanced form of peripheral artery disease, is the only treatment that has shown to reduce amputations. Indeed, all societal guidelines have given a class I indication for revascularization in patients with CLI. However, individuals with CLI frequently present with multilevel disease where >70% have some degree of infrapopliteal invol...

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ژورنال

عنوان ژورنال: ACS Nano

سال: 2015

ISSN: 1936-0851,1936-086X

DOI: 10.1021/nn507269g