Nanoscale drug carriers bypass blood–brain barrier

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Nanoscale drug delivery systems and the blood–brain barrier

The protective properties of the blood-brain barrier (BBB) are conferred by the intricate architecture of its endothelium coupled with multiple specific transport systems expressed on the surface of endothelial cells (ECs) in the brain's vasculature. When the stringent control of the BBB is disrupted, such as following EC damage, substances that are safe for peripheral tissues but toxic to neur...

متن کامل

Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer

Nanoscale carriers are of increasing interest for use in anticancer therapy because they can deliver drugs in a targeted way. Ideally, nanocarriers combine passive and active delivery mechanisms, by integrating targeting ligands on the surface of their stealth corona using simple and efficient conjugation chemistry. This feature article summarizes the conventional and newly explored conjugation...

متن کامل

Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging.

In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading (usually less than 5 wt% of the transported drug versus the carrier material) and/or rapid release of the proportion of the drug that is simply adsorbed (or anchored) at the external surface of the nanocarrier...

متن کامل

Colloidal Drug Carriers

Colloidal drug carrier is one of the most important entities essentially required for successful transport of loaded drugs. They are drug vectors, which sequester, transport and retain the active drug en route, while they elute or deliver it within or in the vicinity of target. Targeting the drug to the desired site of action would not only improve the therapeutic efficacy but also enable a red...

متن کامل

Nanostructured Lipid Drug Carriers

solid lipid carriers – NLC. Particulate lipid matrices in the form of lipid pellets are known from the textbooks since many years, products are on the market (e. g. Mucosolvan retard, Boehringer-Ingelheim). After these lipid pellets as the first generation, P. Speiser developed so-called “lipid nanopellets for oral administration” in the middle of the eighties [1]. This system was not further d...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Materials Today

سال: 2015

ISSN: 1369-7021

DOI: 10.1016/j.mattod.2015.08.007