Nanoparticle-mediated p53 gene therapy for tumor inhibition
نویسندگان
چکیده
منابع مشابه
P53 tumor suppressor gene therapy for cancer.
The last two decades have led to a greater understanding of the genetic basis of human malignancy. Although numerous genetic alterations have been detected in cancer, activation of oncogenes and inactivation of cell cycle regulators (e.g., tumor suppressor genes) are now known to play a critical role in the progression of the disease. Therapeutic strategies based on specific molecular alteratio...
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Gene therapy has the potential to provide cancer treatments based on novel mechanisms of action with potentially low toxicities. This therapy may provide more effective control of locoregional recurrence in diseases like non–small-cell lung cancer (NSCLC) as well as systemic control of micrometastases. Despite current limitations, retroviral and adenoviral vectors can, in certain circumstances,...
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Biomedical application of nanotechnology is a rapidly developing area that raises new prospect in the improvement of diagnosis and treatment of human diseases. The ability to incorporate drugs or genes into a functionalized nanoparticle demonstrates a new era in pharmacotherapy for delivering drugs or genes selectively to tissues or cells. It is envisioned that the transfer of nanoengineering c...
متن کاملIntracerebral adenovirus-mediated p53 tumor suppressor gene therapy for experimental human glioma.
Malignant gliomas of astrocytic origin are good candidates for gene therapy because they have proven incurable with conventional treatments. Although mutation or inactivation of the p53 tumor suppressor gene occurs at early stages in gliomas and is associated with tumor progression, many tumors including high-grade glioblastoma multiforme carry a functionally intact p53 gene. To evaluate the ef...
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The objective of this study is to explore the safety, efficacy, and administration method of the recombinant adenovirus p53 gene (rAd-p53, or gendicine) in the treatment of pulmonary metastasis tumor from advanced hepatocellular carcinoma (HCC). Pulmonary metastasis tumors from HCC in 20 patients were treated by using transcatheter bronchial arterial gendicine infusion combined with transcathet...
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ژورنال
عنوان ژورنال: Drug Delivery and Translational Research
سال: 2011
ISSN: 2190-393X,2190-3948
DOI: 10.1007/s13346-010-0008-9