Nanonization of Niflumic Acid by Co-Grinding

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Nanonization of Niflumic Acid by Co-Grinding

The aim of this study was to produce niflumic acid nanoparticles without using an organic solvent, in order to achieve an increased rate of dissolution of the final products. Co-grinding with excipients was used to decrease the particle size. Poloxamer 188 (P) and mannitol (M) applied as co-grinding materials stabilized the system, preventing aggregation of the nanocrystals. The morphology and ...

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ژورنال

عنوان ژورنال: Advances in Nanoparticles

سال: 2013

ISSN: 2169-0510,2169-0529

DOI: 10.4236/anp.2013.24045