Nanodrug with ROS and pH Dual‐Sensitivity Ameliorates Liver Fibrosis via Multicellular Regulation
نویسندگان
چکیده
منابع مشابه
Valine Ameliorates Liver Fibrosis
It has been reported that treatment with branched chain amino acids (BCAAs) increases the survival rates in cirrhotic patients. In this study, we investigated the effect of L-valine, one of BCAAs, on liver fibrosis in rat. To induce liver fibrosis, male Wistar rats were injected carbon tetrachloride (CCl4) intraperitoneally (2.0 mL/kg) twice a week for 12 weeks. The rats (seven to fifteen rats ...
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Despite earlier notions that intracellular pH (pHi) was invariant with time, recent studies have documented pHi changes of from 0.1 to 1.6 U during metabolic and developmental transitions in a variety of cells. Here we review the evidence for pHi-mediated regulation of gamete activation, cellular dormancy, the cell cycle, and stimulus-response coupling. Intracellular Ca2+ level changes also acc...
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ژورنال
عنوان ژورنال: Advanced Science
سال: 2020
ISSN: 2198-3844,2198-3844
DOI: 10.1002/advs.201903138