Nanobodies (VHHs) for targeting tau in Alzheimer's disease and tauopathies
نویسندگان
چکیده
منابع مشابه
Targeting tau oligomers for therapeutic development for Alzheimer’s disease and tauopathies
Tau protein has a causative role in Alzheimer’s disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neuronal axons. In the disease process tau protein becomes modified, loses its affinity to microtubules and accumulates in the cell bo...
متن کاملTau and tauopathies.
Tau protein is a neuronal microtubule-associated protein (MAP), which localizes primarily in the axon. It is one of the major and most widely distributed MAPs in the central nervous system. Its biochemistry and molecular pathology is being increasingly studied. Tau is a key component of neurofbrillary tangles in Alzheimer's disease (AD). Disorders with neuronal, oligodendroglial or astrocytic f...
متن کاملPET Imaging of Tau Pathology in Alzheimer’s Disease and Tauopathies
Alzheimer’s disease (AD) is a major public health problem affecting nearly 35 million people worldwide with numbers projected to rise to 115.4 million by 2050. Medicare and Medicaid cost of AD is anticipated to increase fourfold to approximately $ 600 billion in the next 40 years. AD is the only cause of death among the top 10 causes that has no prevention or cure (1, 2). AD causes are not full...
متن کاملTau Spreading Mechanisms; Implications for Dysfunctional Tauopathies
Tauopathies comprise a group of progressive age-associated neurodegenerative diseases where tau protein deposits are found as the predominant pathological signature (primary tauopathies) or in combination with the presence of other toxic aggregates (secondary tauopathies). In recent years, emerging evidence suggests that abnormal tau accumulation is mediated through spreading of seeds of the pr...
متن کاملGlial Tau Pathology in Tauopathies: Functional Consequences.
Tauopathies are a class of neurodegenerative diseases characterized by the presence of hyperphosphorylated and aggregated tau pathology in neuronal and glial cells. Though the ratio of neuronal and glial tau aggregates varies across diseases, glial tau aggregates can populate the same degenerating brain regions as neuronal tau aggregates. While much is known about the deleterious consequences o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: IBRO Reports
سال: 2019
ISSN: 2451-8301
DOI: 10.1016/j.ibror.2019.07.325