Nafenopin-induced rat liver peroxisome proliferation reduces DNA methylation by N-nitrosodimethylamine in vivo
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چکیده
منابع مشابه
METHYLA TION OF LIVER DNA OF RAT AND MOUSE BY N-NITROSODIMETHYLAMINE FORMED IN VIVO FROM OlMETHYLAMINE AND NITRITE*
--The extent of formation of N-nitrosodimethylaminc {NDMA) in the stomachs of rats and mice after sirnultancous oral administration of [ C]dimethylamine and potassiu.m nitrite ~as determined by measuring the methylation of liver DNA. With doses of around I mg d1m~thylamm~ hydrochloride/kg body weight and 50 mg potassium nitrite/kg body w~ight. OJ{'\, of the arnme was n:.tr~satcd . on average. T...
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Enzymatic denitrosation is a potentially inactivating metabolic route that has been shown to convert carcinogenic N-nitrosodimethylamine (NDMA) to methylamine (MA) in vitro. To investigate its quantitative course in vivo, groups of 8-week-old male Fischer rats have been given small (8-15 mumol/kg) p.o. or i.v. bolus doses of 14C-labeled NDMA and the subsequent formation of radioactive MA has be...
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Nafenopin (2-methyl-2[p-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy]-propionic acid; Su-13437), a potent hypolipidemic compound, was administered in varying concentrations in ground Purina Chow to male and female rats, wild type (Cs(a) strain) mice and acatalasemic (Cs(b) strain) mice to determine the hepatic microbody proliferative and catalase-inducing effects. In all groups of animals, administra...
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Dibromoacetic acid (DBA) is a drinking water disinfection by-product. Its analogs, dichloroacetic acid (DCA) and trichloroacetic acid (TCA), are liver carcinogens in rodents. We evaluated the ability of DBA to cause DNA hypomethylation, glycogen accumulation, and peroxisome proliferation that are activities previously reported for the two other haloacetic acids. Female B6C3F1 mice and male Fisc...
متن کاملPeroxisome proliferation and lipid peroxidation in rat liver.
Male F344 rats were fed a diet containing the peroxisome proliferators 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropionic acid [ciprofibrate (0.025%)] or [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid [Wy-14643 (0.1%)] for up to 14 months to determine whether hepatic peroxisome proliferation caused by these agents results in the induction of membrane lipid peroxidation in the li...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1985
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/6.9.1309