منابع مشابه
NADPH oxidase: an update.
The O2 generated by this enzyme serves as the starting material for the production of a vast assortment of reactive oxidants, including oxidized halogens, free radicals, and singlet oxygen. These oxidants are used by phagocytes to kill invading microorganisms, but they also cause a lot of what the military would call ‘‘collateral damage’’ to nearby tissues, so their production has to be tightly...
متن کاملphagocytosis, and NADPH oxidase
The contributing role of environmental factors to the development of Parkinson’s disease has become increasingly evident. We report that mesencephalic neuron-glia cultures treated with diesel exhaust particles (DEP; 0.22 μM) (5–50 μg/ml) resulted in a dose-dependent decrease in dopaminergic (DA) neurons, as determined by DA-uptake assay and tyrosine-hydroxylase immunocytochemistry (ICC). The se...
متن کاملNADPH Oxidase and Neurodegeneration
NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide via the reduction of molecular oxygen. Nox-derived reactive oxygen species (ROS) are known to be involved in a variety of physiological processes, including host defense and signal transduction. However, over the past decade, the involvement of (Nox)-dependent oxidative stress in ...
متن کاملA Multifarious NADPH Oxidase
Nox4, one of the 7 isoforms of the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase family that generate reactive oxygen species, was first identified in the early 2000s in kidneys.1 Nox4 was originally described as an oxygen sensor and regulator of kidney cell growth and because of its renal abundance was termed “renox.”1 It soon became evident that Nox4 has a ubiquitous distributio...
متن کاملNox4, the Good NADPH Oxidase!
NADPH oxidases of the Nox family are enzymes whose only known function is the production of reactive oxygen species (ROS). Since the first report on a vascular NADPH oxidase by Griendling et al in 1994,1 several thousand publications have been devoted to this topic. The general impression is that under physiological conditions, Nox proteins contribute to vascular signaling, whereas the overacti...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2000
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.86.5.494