Na-K-2Cl cotransporter inhibition impairs human lung cellular proliferation
نویسندگان
چکیده
منابع مشابه
Na-K-2Cl cotransporter inhibition impairs human lung cellular proliferation.
The widespread presence of the Na-K-2Cl (NKCC) cotransporter protein suggests that chronic administration of inhibitors may result in adverse effects. Inhibition of the NKCC cotransporter by loop diuretics is felt to underlie the diuretic and the pulmonary smooth muscle relaxant effects of this drug class. However, the fundamental regulation of salt and water movement by this cotransporter sugg...
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متن کاملImmunolocalization of a Na-K-2Cl cotransporter in human tracheobronchial smooth muscle.
Inhibition of the Na-K-2Cl (NKCC) cotransporter by loop diuretics is associated with airway relaxation, but there has been no direct evidence for the expression of this protein in airway smooth muscle. Thus we hypothesized that a NKCC cotransporter is present and functional in airway smooth muscle cells. Monoclonal and polyclonal antibodies were used first to demonstrate the presence of a NKCC ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2004
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00021.2004