N6-methyladenine: a potential epigenetic mark in eukaryotes
نویسندگان
چکیده
منابع مشابه
N6-methyladenine: a potential epigenetic mark in eukaryotes
Methylation modifications in DNA in the forms of 5-methylcytosine (5mC) and N 6-methyladenine (6mA) are one of the most important epigenetic marks that have been proposed to regulate gene expression and control numerous cellular and biological processes. The prevailing view is that, while 5mC serves as the predominant type, if not the only type, of methylated base in mammals to regulate gene ex...
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Chromatin, consisting of deoxyribonucleic acid (DNA) wrapped around histone proteins, facilitates DNA compaction and allows identical DNA codes to confer many different cellular phenotypes. This biological versatility is accomplished in large part by posttranslational modifications to histones and chemical modifications to DNA. These modifications direct the cellular machinery to expand or comp...
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DNA N(6)-methyladenine (6mA) modification is commonly found in microbial genomes and plays important functions in regulating numerous biological processes in bacteria. However, whether 6mA occurs and what its potential roles are in higher-eukaryote cells remain unknown. Here, we show that 6mA is present in Drosophila genome and that the 6mA modification is dynamic and is regulated by the Drosop...
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DNA N6-methyladenine (6mA) protects against restriction enzymes in bacteria. However, isolated reports have suggested additional activities and its presence in other organisms, such as unicellular eukaryotes. New data now find that 6mA may have a gene regulatory function in green alga, worm, and fly, suggesting m6A as a potential "epigenetic" mark.
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Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA Department of Chemistry, Princeton University, Princeton, NJ 08544, USA Epigenetics Program, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Room 9-124, 3400 Civic Center Boulevard, Building 421, Philadelphia, Pennsylvania 19104, United States. Depar...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.4684