N-Methylation of Nicotine and Cotinine in Vivo
نویسندگان
چکیده
منابع مشابه
N-Methylation of Nicotine and Cotinine in Vkm*
In studies on the metabolism of randomly labeled ( -)-nicotine-C4 in the anesthetized dog, it has been observed (2, 3) that the major part of the administered radioactivity, approximately 80 to 90$&, appears in the urine. Approximately one-tenth of this radioactivity is present as nicotine. From various experiments in which unlabeled (-)-nicotine and one of its metabolites, (-)-cotinine, have b...
متن کاملEthnic differences in N-glucuronidation of nicotine and cotinine.
We previously reported that the metabolism of cotinine, the proximate metabolite of nicotine, is significantly slower in black than in white cigarette smokers. To understand why the metabolism of nicotine and cotinine might differ between blacks and whites, we studied the pattern of nicotine metabolism in blacks and whites. One hundred eight healthy smokers (51 blacks and 57 whites), of similar...
متن کاملThe Concentration of Nicotine in Indoor Air of the Cafes of Tehran and the Biological Levels of Nicotine and Cotinine in Exposed Smokers in These Cafes
Background & objectives: The number of waterpipe cafes has considerably grown in Tehran and other cities of Iran. This increase has occurred due to a wrong belief that the use of hookahs is harmless and relatively safe. So, the aim of current study is to investigate the nicotine concentration in the indoor air of the waterpipe and cigarette cafés as well as the biological concentration of nicot...
متن کاملCharacterization of nicotine and cotinine N-glucuronidations in human liver microsomes.
The nicotine and cotinine N-glucuronidations in human liver microsomes were characterized. The Eadie-Hofstee plots of nicotine N-glucuronidation in human liver microsomes were clearly biphasic, indicating the involvement of multiple enzymes. The apparent K(m) and V(max) values were 33.1 +/- 28.1 micro M and 60.0 +/- 21.0 pmol/min/mg and 284.7 +/- 122.0 micro M and 124.0 +/- 44.0 pmol/min/mg for...
متن کاملGas-liquid chromatographic determination of nicotine and cotinine in plasma.
We report a procedure for determining nicotine and cotinine in plasma. Nicotine is extracted from 1 ml of plasma with diethyl ether, back extracted, and analyzed by gas-liquid chromatography with a nitrogen/phosphorus detector. Nicotine and its internal standard, modaline, had retention times of 1.9 and 2.9 min, respectively. Cotinine is then extracted from the same plasma with dichloromethane ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1963
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)81325-4