N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium: proposal for a common catalytic mechanism of arylamine acetyltransferase enzymes.

N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium: proposal for a common catalytic mechanism of arylamine acetyltransferase enzymes.

Acetyl-CoA:N-hydroxyarylamine O-acetyltransferase is an enzyme involved in the metabolic activation of N-hydroxyarylamines derived from mutagenic and carcinogenic aromatic amines and nitroarenes. The O-acetyltransferase gene of Salmonella typhimurium has been cloned, and new Ames tester substrains highly sensitive to mutagenic aromatic amines and nitroarenes have been established in our laborat...

Purification of hepatic polymorphic arylamine N-acetyltransferase from homozygous rapid acetylator inbred hamster: identity with polymorphic N-hydroxyarylamine-O-acetyltransferase.

The polymorphic acetyltransferase isozyme expressed in homozygous rapid acetylator inbred hamster liver cytosol was purified over 2000-fold by sequential Q-Sepharose fast-flow anion-exchange chromatography, Sephacryl S-200 high-resolution size-exclusion chromatography, Mono Q anion-exchange fast-protein liquid chromatography, and preparative polyacrylamide gel electrophoresis. The isozyme migra...

Arylamine N-acetyltransferase.

304 3.5. Namboodiri. kl. A. A,. Nakai. C‘. k Klein, 1). C. (1070) J. Ncurochem. 33. 807-810 30. Klein. 1). C’. k Namboodiri, M. A. A. (1082) Trends Biochem. Sci. 7, OXI02 37. Namboodiri, M. A. A,, Weller, J. I , . Kc Klein, I). C’. (1080) J. l k l . Cheni. 255. 6032-0035 38. Namboodiri, M. A. A,. Weller, J. I, . K: Klein, I). C’. ( 1080) Hiochem. Hiophys. Kes. C’ommun. 96, 1 8%1 05 30 . Niimboo...

NAT 2 ( N - acetyltransferase 2 ( arylamine N - acetyltransferase ) )

NAT 1 ( N - acetyltransferase 1 ( arylamine N - acetyltransferase ) )

The human NAT1 gene has nine exons. The coding region is located in exon 9 and spans 870 bp. Diverse NAT1 transcripts have been reported and two promoters exist. The first promoter, designated as P1 is located in the 5' flanking region of exon 1 and controls two major (a1 and a2) transcripts. The second promoter is located upstream of exon 4 and give rise to at least five (b1 to b5) different t...