N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53
نویسندگان
چکیده
منابع مشابه
ERGIC-53 and traffic in the secretory pathway.
The ER-Golgi intermediate compartment (ERGIC) marker ERGIC-53 is a mannose-specific membrane lectin operating as a cargo receptor for the transport of glycoproteins from the ER to the ERGIC. Lack of functional ERGIC-53 leads to a selective defect in secretion of glycoproteins in cultured cells and to hemophilia in humans. Beyond its interest as a transport receptor, ERGIC-53 is an attractive pr...
متن کاملRecycling of the endoplasmic reticulum/Golgi intermediate compartment protein ERGIC-53 in the secretory pathway.
semi-intact cells. VGMs appear dispersed throughout the cytoplasm following IQ treatment, while stacks appear as large discrete aggregates by immunofluorescence in intact cells after removal of IQ [12,13]. This assay exploits the ability to distinguish the relative distribution of VGMs and the stacks of Golgi cisternae by immunofluorescence microscopy using Golgi-specific antibodies. Electron m...
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abstract while task-based instruction is considered as the most effective way to learn a language in the related literature, it is oversimplified on various grounds. different variables may affect how students are engaged with not only the language but also with the task itself. the present study was conducted to investigate language and task related engagement on the basis of the task typolog...
15 صفحه اولthe role of russia in transmission of energy from central asia and caucuses to european union
پس ازفروپاشی شوروی،رشد منابع نفت و گاز، آسیای میانه و قفقاز را در یک بازی ژئوپلتیکی انرژی قرار داده است. با در نظر گرفتن این منابع هیدروکربنی، این منطقه به یک میدانجنگ و رقابت تجاری برای بازی های ژئوپلتیکی قدرت های بزرگ جهانی تبدیل شده است. روسیه منطقه را به عنوان حیات خلوت خود تلقی نموده و علاقمند به حفظ حضورش می باشد تا همانند گذشته گاز طبیعی را به وسیله خط لوله مرکزی دریافت و به عنوان یک واس...
15 صفحه اولTargeting of Protein ERGIC-53 to the ER/ERGIC/cis-Golffl Recycling Pathway
ERGIC-53 is a lectin-type membrane protein that continuously recycles between the ER, ERGolgi intermediate compartment (ERGIC) and the cisGolgi. To identify the targeting signals that mediate this recycling, N-glycosylated and myc-tagged variants of ERGIC-53 were constructed. By monitoring endoglycosidase H resistance, we measured the loss from the ER-ERGIC-cis-Golgi cycle of ERGIC-53. A domain...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2006
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2006.06.018