N-alkylation of isatins utilizing KF/alumina
نویسندگان
چکیده
منابع مشابه
Enantioselective N-alkylation of isatins and synthesis of chiral N-alkylated indoles.
Asymmetric N-alkylations of isatins with enals were shown to be feasible via a prolinol-catalyzed iminium activation, and N-alkylated isatins were obtained in good yields and with excellent enantioselectivity. The biologically useful N-alkylated isatins also served as valuable synthetic precursors, and could be readily converted to chiral N-alkylated indole derivatives. The described method pro...
متن کاملMechanochemical N-alkylation of imides
The mechanochemical N-alkylation of imide derivatives was studied. Reactions under solvent-free conditions in a ball mill gave good yields and could be put in place of the classical solution conditions. The method is general and can be applied to various imides and alkyl halides. Phthalimides prepared under ball milling conditions were used in a mechanochemical Gabriel synthesis of amines by th...
متن کاملSynthesis of N-alkyl isatins via oxidative cyclization of N-alkyl 2-bromo(chloro)acetanilides.
A highly efficient method for the synthesis of N-alkyl isatins starting from N-alkyl 2-bromo or 2-chloro acetanilides is described. The starting materials are easy to prepare and the yields of isatins are generally high. Operationally the reaction is very simple to run. Even though best results were obtained with a catalytic amount of CuI, the reactions of N-alkyl 2-bromo acetanilides actually ...
متن کاملThe Selective N-Alkylation of Monoethanolamine
Alkyl derivatives of MEA are used in the production of surfactants, dyes, in the manufacture of drugs as a buffer substance and for the stabilization of emulsions, in the manufacture of herbicides, cosmetics, antihistamines, are also of practical interest [1]. It is widely known also as useful “acid” gases (H2S, CO2, SO2, etc.) as absorbents in the process of cleaning process for gases in oil r...
متن کاملThe Selective N-Alkylation of Monoethanolamine
Alkyl derivatives of MEA are used in the production of surfactants, dyes, in the manufacture of drugs as a buffer substance and for the stabilization of emulsions, in the manufacture of herbicides, cosmetics, antihistamines, are also of practical interest [1]. It is widely known also as useful “acid” gases (H2S, CO2, SO2, etc.) as absorbents in the process of cleaning process for gases in oil r...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2012
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0013.629