Myosin repertoire expansion coincides with eukaryotic diversification in the Mesoproterozoic era
نویسندگان
چکیده
منابع مشابه
VH replacement in primary immunoglobulin repertoire diversification.
The genes encoding the variable (V) region of the B-cell antigen receptor (BCR) are assembled from V, D (diversity), and J (joining) elements through a RAG-mediated recombination process that relies on the recognition of recombination signal sequences (RSSs) flanking the individual elements. Secondary V(D)J rearrangement modifies the original Ig rearrangement if a nonproductive original joint i...
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The Cambrian explosion can be thought of as the culmination of a diversification of eukaryotes that had begun several hundred million years before. Eukaryotes – one of the three domains of life — originated by late Archean time, and probably underwent a long period of stem group evolution during the Paleoproterozoic Era. A suite of taxonomically resolved body fossils and biomarkers, together wi...
متن کاملSecondary mechanisms of diversification in the human antibody repertoire
V(D)J recombination and somatic hypermutation (SHM) are the primary mechanisms for diversification of the human antibody repertoire. These mechanisms allow for rapid humoral immune responses to a wide range of pathogenic challenges. V(D)J recombination efficiently generate a virtually limitless diversity through random recombination of variable (V), diversity (D), and joining (J) genes with div...
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—Well-preserved microfossils occur in abundance through more than 1000m of lower Mesoproterozoic siliciclastic rocks composing the Roper Group, Northern Territory, Australia. The Roper assemblage includes 34 taxa, five interpreted unambiguously as eukaryotes, nine as possible eukaryotes (including Blastanosphaira kokkoda new genus and new species, a budding spheromorph with thin chagrinate wall...
متن کاملPhylogenetic diversification of immunoglobulin genes and the antibody repertoire.
Immunoglobulins are encoded by a large multigene system that undergoes somatic rearrangement and additional genetic change during the development of immunoglobulin-producing cells. Inducible antibody and antibody-like responses are found in all vertebrates. However, immunoglobulin possessing disulfide-bonded heavy and light chains and domain-type organization has been described only in represen...
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ژورنال
عنوان ژورنال: BMC Evolutionary Biology
سال: 2017
ISSN: 1471-2148
DOI: 10.1186/s12862-017-1056-2