Myocyte Specific Overexpression of Myoglobin Impairs Angiogenesis After Hind-Limb Ischemia
نویسندگان
چکیده
منابع مشابه
Myocyte specific overexpression of myoglobin impairs angiogenesis after hind-limb ischemia.
OBJECTIVE In preclinical models of peripheral arterial disease the angiogenic response is typically robust, though it can be impaired in conditions such as hypercholesterolemia and diabetes where the endothelium is dysfunctional. Myoglobin (Mb) is expressed exclusively in striated muscle cells. We hypothesized that myocyte specific overexpression of myoglobin attenuates ischemia-induced angioge...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2008
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.108.170951