Myocardial protection with mild hypothermia

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SPOTLIGHT REVIEW Myocardial protection with mild hypothermia

Mild hypothermia, 32–358C, is very potent at reducing myocardial infarct size in rabbits, dogs, sheep, pigs, and rats. The benefit is directly related to reduction in normothermic ischaemic time, supporting the relevance of early and rapid cooling. The cardioprotective effect of mild hypothermia is not limited to its recognized reduction of infarct size, but also results in conservation of post...

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Therapeutic Hypothermia for Myocardial Protection in ST Elevation Myocardial Infarction

Following the return of spontaneous circulation after cardiac arrest, the use of therapeutic hypothermia (TH) has been demonstrated to improve neurologic outcomes and mortality. The potential cardiac benefits and the role of induced hypothermia as a cardioprotective strategy are less clear. Numerous laboratory and clinical studies implicate both inciting myocardial ischemia and subsequent reper...

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Fundamental research progress of mild hypothermia in cerebral protection

Through the years, the clinical application of mild hypothermia has been carried out worldwide and is built from the exploration and cognition of neuroprotection mechanisms by hypothermia. However, within the last decade, extensive and fundamental researches in this area have been conducted. In addition to aspects of the previous findings, scholars have discovered several new contents and uncer...

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Current status of cerebral protection with mild-to-moderate hypothermia after traumatic brain injury.

PURPOSE OF REVIEW The aim of this article is to review the current status of protective effects of mild-to-moderate hypothermia on traumatic brain injury. RECENT FINDINGS More than 30 clinical studies have reported effects of therapeutic hypothermia on outcome of traumatic brain injury and cerebral ischemia. Only one clinical trial of short-term mild hypothermia did not show any effect in pat...

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Impact of Mild Hypothermia on the Recovery of Patients with Acute Stroke

Background and Objective: Hypothermia induction has been proposed to improve the recovery process of stroke in the last two decades. Therefore, the aim of this study was to investigate the effect of mild hypothermia on the recovery of patients with acute stroke. Materials and Methods: This single-blind randomized clinical trial was conducted on 60 patients with acute stroke in 2018 in Hamadan,...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 2011

ISSN: 0008-6363

DOI: 10.1093/cvr/cvr315