Myocardial, Perivascular, and Epicardial Fat

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Myocardial, Perivascular, and Epicardial Fat

Myocardial fat content refers to the storage of triglyceride droplets within cardiomyocytes. In addition, the heart and arteries are surrounded by layers of adipose tissue, exerting vasocrine and paracrine control of the subtending tissues. The rapid development of the field of noninvasive imaging has made it possible to quantify ectopic fat masses and contents with an increasing degree of accu...

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Perivascular Fat, Thermogenesis, and Atherosclerosis

The Evolving View of Fat The relationship between increased body mass index and risk for diabetes mellitus or cardiovascular disease is well established. Such observations have driven considerable interest into the nature of adipose tissue and what mechanisms might help explain how adipose tissue and specific aspects of adipocyte biology influence cardiometabolic disorders. For example, adipocy...

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Local Production of Fatty Acid-Binding Protein 4 in Epicardial/Perivascular Fat and Macrophages Is Linked to Coronary Atherosclerosis.

OBJECTIVE Fatty acid-binding protein 4 (FABP4) is expressed in adipocytes and macrophages, and elevated circulating FABP4 level is associated with obesity-mediated metabolic phenotype. We systematically investigated roles of FABP4 in the development of coronary artery atherosclerosis. APPROACH AND RESULTS First, by immunohistochemical analyses, we found that FABP4 was expressed in macrophages...

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Epicardial fat thickness and cardiovascular involvements.

Dear Editor, We have read the article ” Epicardial fat thickness(EFT) in patients with rheumatoid arthritis” written by Erdem et al. with a great interest.1 The authors aimed to explain the relationship between epicardial fat thickness and clinical and echocardiographic parameters in patients with rheumatoid arthritis. They concluded that EFT as an indicator of cardiovascular involvement was hi...

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Epicardial Fat and Atrial Fibrillation: A Review.

Atrial fibrillation (AF) is a progressive disorder that increases with age. Obesity is an important risk factor for AF. Pericardial fat is an active adipose tissue in close proximity to the heart and has been shown to be a risk factor for structural as well as coronary artery disease independent of body mass index. Recent studies suggest a role of epicardial fat in atrial remodeling as well as ...

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ژورنال

عنوان ژورنال: Diabetes Care

سال: 2011

ISSN: 0149-5992,1935-5548

DOI: 10.2337/dc11-s250